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Nagle's algorithm is just a special case of TCP worst case latency. Packet loss and congestion also cause significant latency.

If you care about latency, you should consider something datagram oriented like UDP or SCTP.

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What if occasional latency is fine, and latency on terrible networks with high packet loss is fine, but you want the happy case to have little latency? Both many (non-competitive) games and SSH falls into this: reliability is more important than achieving the absolute lowest latency possible, but lower latency is still better than higher latency.

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