> Every time I've used as a CAD GUI program I would get to this point where I would need to alter a single dimension by 0.25mm and realize that _all_ of my fastener holes, cutouts, etc have to be nudged with the keyboard or mouse to accommodate it.
There seems to be some fundamental misunderstanding of CAD here. I can't imagine how you could even design something in CAD in a way that you would end up in this situation.