Just as an example: today, at a talk, I was talking to this woman and we had a pleasant conversation. Then, as the talk is about to start, she says something to the effect of "I'd love to learn more about your work". My response (with a mouthful of pizza)? "Sure!". And then I focused back on the speaker as he was about to start speaking. Much later I realized she wanted to continue the conversation later, and wanted my card or some contact info. But by then she was gone (she left early).
So, for me, it's not that I don't pick up signals; I do pick up many, but they have a much lower priority in the brain's CPU and my responses don't incorporate the signals. My brain finally realizes the inputs way after the opportunity has passed.
I realize now that I've learned to 'lean into the discomfort,' but I still have those feelings almost all the time...