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Set `browser.low_commit_space_threshold_mb` and/or `browser.low_commit_space_threshold_percent` to something you'd prefer, and confirm that `browser.tabs.unloadOnLowMemory` is set (I think it is by default).

The default settings are to allow it to acquire memory until memory pressure on the system reaches 5% free, at which point it will begin freeing memory. You can set a custom percentage or a specific amount of memory.

That or just run it in a cgroup with a memory limit.

Are you sure it is not malware? When was the last time you changed the profile?

Also, I have a ton of bookmarks and as I been slowly deleting them Firefox's performance has improved. This same giant size of bookmarks Chrome seems to sync out of order causing their placement to change.

Ublock origin also does slow down the browser a bit on websites that.. don't.. have ads.

Do you use Auto Tab Discard?

https://addons.mozilla.org/en-US/firefox/addon/auto-tab-disc...

Go to about:processes and kill whichever website's subprocess is using the most memory. Sometimes it's the main process but more commonly it's a specific site. Looking at You, Tube.