Biggest drawback though is that it's over-optimized for matrix math, that it forces you to think about everything as matrices, even if that's not how your data naturally lies. The first thing they teach about performant Matlab code is that simple for-loops will tank performance. And you feel it pretty quickly, I saw a case once of some image processing, with a 1000x speedup from Matlab-optimized syntax.
Other things issues I've run into are string handling (painful), and generally OOP is unnatural. Would love to see something with the convenient math syntax of Matlab, but with broader ease of use of something like JS.