Counterargument... I do technical diligence so I talk to a lot of companies at points of inflection, and I also talk to lots who are stuck.

The ability to rapidly shard everything can be extremely valuable. The difference between "we can shard on a dime" and "sharding will take a bunch of careful work" can be expensive If the company has poor margins, this can be the difference between "can scale easily" and "we're not getting this investment".

I would argue that if your folks have the technical chops to be able to shard while avoiding surrogate guaranteed unique keys, great. But if they don't.... a UUID on every table can be a massive get-out-of-jail free card and for many companies this is much, much important than some minor space and time optimizations on the DB.

Worth thinking about.