This is killing me with complexity.
We had agents.md and were supposed to augment the context there.
Now back to cursor rules and another md file to ingest.
You can absolutely have a skill that tells the coding agent how to use Python with your preferred virtual environment mechanism.
I ended up solving that in a slightly different way - I have a Claude hook that spits attempts to run "python" or "python3" and returns an error saying "use uv run instead".