What’s wrong with Gnome’s multi monitor support? My two monitors even have different pixel density.
E.G. can you set one screen to 150% and one to 175%? (I think the answer to this is 'technically yes but then everything goes a bit blurry because they do it by rendering at 2x then downscaling')
Proper mixed dpi scaling means stuff will render pixel-perfectly instead of downscaling hacks.
I did have to get a reasonably new Gnome, Ubuntu LTS had one that was broken with fractional scaling.