Hard disagree. Not having access to true device pixels is a feature, not a bug -- especially when you consider that common screens today range from 90 dpi to 600 dpi. And then not to mention browser zoom on top of that.
Trying to optimize to some kind of perfect pixel alignment shouldn't be a goal anymore. We use antialiasing instead to ensure that widths and weights maintain proportionality no matter what resolution and zoom level you use. Trying to snap to pixels is an anti-feature with modern screens. It made sense when everyone used low-resolution screens and antialiasing wasn't commonly used in OS's and programs. But it hasn't made sense for well over a decade now.