>A civilization that built a Dyson Sphere would have to go to great lengths to avoid detection, either by getting rid of its waste heat in some novel way, or by building massive radiators that give off heat so cool that it would be undetectable against the cosmic microwave background, the faint afterglow of the Big Bang.

So if a civilization were to completely mask itself in the EM spectrum, the only way to detect them would be to look for gravitational distortions assuming those can't be masked. A civilization might do this either to hide from others or because the maximum efficiency of their energy extraction system would occur when their waste heat matched the background ration. So a really advanced (and paranoid or efficient) civilization would be indistinguishable from dark matter.

This brings up another interesting hypothesis: dark matter is actually the computronium of all of the alien civilizations in the universe that have achieved a technological singularity. Unfortunately, this hypothesis can't be tested until humanity gets to the same level.