I mean, if you were deathly allergic to eggs in the 1800s, you died. Very early.
If smoke sent you into respiratory distress, you died. Very early.
Or see the "left-handedness epidemic". It is probably not massively more prevalent now than it was in 1900s, even if that's what the stats say. https://www.researchgate.net/figure/The-overall-rate-of-left...