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I use http://ghostery.com as a Chrome extension. There's also http://disconnect.me, also extension based.

Then there's the more extreme route of using Tor for all browsing.

Is there a point to using both of them? I just ended up using only Ghostery a while ago, because running five potentially redundant extensions seemed to do more harm than good with the hits to performance.

For Firefox, there is an Adblock subscription called "Antisocial" http://adblockplus.org/en/subscriptions (at the bottom of the page)

The facebook button is an iframe that links to a particular URL. You block that URL (+wildcard) in your browser.

Ghostery and antisocial are curated fOr you. But if you prefer more control, requestpolicy is recommended.

Run NoScript, never whitelist facebook. Crude but effective.

This only prevents FB scripts from executing, but you still get the images ( and FB the cookies). So this is not the solution for the paranoid.

Using ScriptNo(chrome plugin) in AntiSocial mode works too.