3E 00 : I was on MSX and never had an assembler when you so I only remember the Hex, never actually knew the instructions; I wrote programs/games by data 3E,00,CD,etc without comments saying LD A as I never knew those at the time.
Back in 1985 I did some hand-coding like this because I didn't have access to an assembler: https://blog.jgc.org/2013/04/how-i-coded-in-1985.html and I typed the whole program in through the keypad.
Later still I'd be patching binaries to ensure their serial-checks passed, on Intel.
I'm quite sure none of my friends knew any CPU opcode; however, people usually remembered a few phone numbers.
I didn't know you could do it differently for years after I started.