Thats the point to many things in life that you just make it more difficult and most people won’t be bothered to attempt to circumvent whatever it is.
There will still be circumventers but it is will be less than if you just said fuck it.
And if someone does the kernel bypass thing, well, rely on server-side heuristics (which are imperfect, but also unknowable to the attacker) and you'll discourage enough of that with account bans.
Helpfully eSports players tend to have video captures of their gameplay, and most of these "undetectable" cheats are real obvious if you actually watch the footage. That catches most of the serious stuff at the upper level. It's why video verification has been a thing in the speedrunning scene for such a long time.
Anyone can do that, but not anyone can simply “patch the kernel” and such.
Sure they can - download this pre-patched ISO and boot it in QEMU. Now you have a modified kernel, _and_ you’re not running dodgy spyware on your PC.
There's a subreddit called /r/vacsucks which is full of pro players blatantly cheating and getting away with it while the rest of the idiots think they're just good players.
Or, depending on your point of view, full of idiots flagging any player better than they are as cheating.
Aimbots can be "humanized" enough that any such determination becomes subjective.