Same is true for: insulin, Levothyroxine, Antiretroviral Therapy (HIV), Enzyme Replacement Therapy ( Pompe Disease or Gaucher Disease, antipsychotic medications for severe schizophrenia. And many others. And here’s the interesting twist, the closer the Number Needed to treat is to 1, the more helpful the medication should be viewed. All these medications have an extremely low NNT, including GLP1s.