Not sure I agree. Also depends of the domain. The python ecosystem is of course a lot richer for anything AI. But try to open, manipulate and export spreadsheets. In python you pretty much need a different library for every excel file format (xls, xlsx, etc) and usually the more file formats a library can handle, the least capable it is (eg pandas). In .net you have libraries like spreadsheetgear that are super powerful, including their own excel calculation engine. I see nothing remotely close in python.