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It's strange that you have a problem with Flask in production. What I've heard, there shouldn't be much of a problem with it. It should easily be able to handle 1,000 basic requests per second.

Have you done any performance analysis to figure out where the bottlenecks might be? Have you tried the flask-debugtoolbar (http://pypi.python.org/pypi/Flask-DebugToolbar)? How many requests do you get? What's the load average of the process? Is there an un-indexed SQL query you don't know about? In the most extreme case, have you put a debugging sleep(1) call in your code which you've forgotten to remove?

Without knowing more about where your Flask app is being bogged down, it's not that worthwhile to switch to pypy.

Are you sure your app is not db or I/O bound? I would suggest giving https://github.com/mgood/flask-debugtoolbar a try and getting some numbers before making a switch.

Can you elaborate on what is not performing well?