It shouldn't make any difference where you pin it, it's systemic it just has to be administered subcutaneously because it's a peptide and it isn't orally active.
Don't listen to these YouTubers about health and fitness, most of them are clueless
Don't listen to these YouTubers about health and fitness, most of them are clueless
Usually this type of anecdata becomes the basis of legitimate, controlled studies and over time can inform and/or adjust.
It would be premature to simply write off all influencers or limiting to only accept the medical profession as the immutable truth.
The reality tends to exist somewhere in the middle, outside of a formal proof.
I've listened to many health influencers and among the legitimate and balanced tend to be Rhonda Patrick and Peter Attia.
Attia provides guidelines for how to think about items, but usually it's the fan base that tends to sully the messaging as the base tends to be far more polarized and dogmatic over bits.
It is interesting to see that there is another poster confirming a slightly different effect though. Regardless of things being "systemic", just understanding that fluids dynamics are complex, I imagine diffusion of a systemic molecule like GLp1 could possibly be variable? Or perhaps there is a localized tissue fatigue?
Many potential options do exist to propose as hypothesis.
He really shouldn't be lumped in with the general "health and fitness Youtubers".
Slower absorption in the thigh may blunt the immediate peak dosing and the acute hunger effects.
As always, the small details matter. I'd guess that pharmacology also has their own thundering herd problem with the dosing of certain drugs.
One of the interesting bits about pharmacology seems to not be the active molecule as much as the innovations in delivery mechanism.