If it's all upside, then I'm happy to be wrong.
[0]: https://www.aao.org/newsroom/news-releases/detail/do-glp-1-d...
Personally, I went from mild background retinopathy to PDR and getting laser treatment in about 3 months. My ophthalmologist (who has an academic background) didn't really know if this diagnosis had the same "quality" of someone who "naturally" progresses to PDR, but some studies say it's transient.
Also, isn't the dose used to treat obesity 3 times higher than the dose used over those 20 years to treat diabetes?
Getting people to eat more broccoli is almost entirely upside. Sure a handful of people will be allergic or whatever, but on a population level some interventions are just one positive after another, and there's no reason it has to be a deal made with the devil.
It really depends on the person, though. They worked for me for a while and don't work now, but I'm a small minority, from what I've heard from people. When they worked, they were great.
It does make me choose more dense meals though since I know I can't eat that much due to delayed gastric emptying. But I have to budget some room for prunes to counteract the constipation. It definitely makes you think about what you eat.
Usually you don't get a free lunch with such a compound.
Without it I'd die sooner anyway.
Having that on a repeat loop is no fun. Getting rid of it is worth all of the mild side effects and cost.
(my partner is on a GLP-1, and lost ~25 lbs in 3 months)
Many of us wish we didn't have to drive a car. Many of us also wish we didn't live in a world where hyperprocessed foods weren't the norm
Coincidentally also a factor of why many Americans take GLP-1 frugs
Up until the end of WWII, automobile ownership was relatively limited. It was just beginning to accelerate at the beginning of the war (in the US), but rationing and war-time defence manufacturing curbed that trend, and sustained rates of alternative transport, particularly rail.
Post-war, there was a mass-consumer blitz, much of it revolving around automobiles, and changes such as commuter suburbs (based around automobiles), superhighways, self-service grocery stores, shopping malls, and strip-mall based retail development began, all trends which evolved over the next 50+ years.
In the 1970s and 1980s, it was quite common for children to walk or ride bikes to school, or take a school bus (which involved walking several blocks to a nearby stop). Since the late 1990s, far more seem to be ferried in private cars, usually by parents, who spend a half-hour or more in pick-up lines. It's not uncommon for children walking along neighbourhood streets to be reported (and collected) by authorities by concern for their safety, and their parents subject to investigation or worse. Suburban, and even urban development patterns have been to ever-lower-density and far more bike- and pedstrian-unfriendly modes.
Recreational, occupational, educational, and other transport and activity patterns are largely away from self-powered movement (walking, cycling, etc.) and toward motorised options (sometimes including e-bikes, electric scooters, or equivalents, though most often automobiles).
Societal change and consequent impacts take time and have long lags.
When the side effects are better understood I suspect for the average person, eating less would be a net benefit to their overall health - _even if they don't lose any weight_.
While it might mean the incident rare of some things goes up, those that it reduces are far more impactful and where far more likely to have mortality issues. Sort of like how Chemotherapy is poisonous but potential has better long term odds, only chemo is far more extreme than GPL1.
Time will tell but so far it is looking kind of good with a few lesser issues.
Which is ironic because someone at Microsoft once called the GPL "cancer".
That said, the negative side effects look to be incredibly rare and manageable (including via stopping treatment) -- and the positives are quite tremendous.
It's not a magic drug, but it is the first of it's kind with such a skew to the positive on side effects.
It actually is a magic drug. The same way ultra-palatable food is also not natural.
That's not what evolution is, at all
That said, it's probably certain enough for me to be open enough to using them now, if my doctor recommends it.
Also It causes constipation apparently, which for most of them is not that much of an issue, but given that I've IBS-C, I'm happy to not have to take it.I have suffered almost the entire gamut of side effects from the beginning until I tried split dosing twice a week, and even then there’s still the occasional instance of me learning that I should not have eaten that and the following 9 hours are going to revolve around stomach pain.
My partner’s journey on the other hand has been smooth sailing the entire time.
YMMV, do your own research but definitely double check any search results with your doctor first… lots of urban myths going around.
I do recommend it though, I am the healthiest I’ve been in literally 10 years.
Only on week 3 but it's been a rollercoaster. It seems to have quite a broad spectrum of effects. I'm still not sure I'll be able to stay on it but losing 10 pounds is a nice counterpoint to the side-effects.
We know there are downsides. They’re just irrelevant compared to being obese. (Or alcoholic. Or, potentially, overweight.)
It might be a vitamin, where there literally aren’t any downsides. I’m sceptical of that. But to the degree there is mass cognitive bias in respect of GLP-1s, it’s against them. (I suspect these are sour grapes due to the drugs being unreachable for many.)
My frank concern is we’re separating into a social media addicted, unvaccinated and obese population on one hand and a wealthy, insured, disease free and fit one on the other. Those are dangerous class and physical divides to risk becoming heritable (socially, not genetically).
My hope is the "waiting for the other shoe to drop" folks are just expressing sour grapes.
If it runs deeper and merges with the anti-vaxers, we've got a behavioural problem fuelling a class divide. That is my fear.
My opinion has shifted over the years. At first I also thought it was largely just sour grapes re: accessibility and fear of the unknown, but now I’m thinking that a large number of people are going to be so far deep into anti-GLP opinions and hot takes they can’t backtrack out of it. Much like political or social beliefs you make into your identity. Too embarrassing to admit you might be wrong.
I know you’re alluding to the same thing, it’s just interesting to me someone else in the world seems to share these thoughts. I also think it may really delineate a multi-generational class divide that is hard to break.
Or all the folks on GLP-1s will develop some rare form of cancer and die early leaving the world to the so-called haters.
Well, read up the testimony of those who stopped taking it for adverse effects, such as nonexistent intestinal transit and -yuck- sulfur burps.
Healthy, non-obese individuals likely aren't seeing these "benefits"... But I'm not a doctor, I just pretend to be one on the Internet.
Well, now it's actionable. No magic, just adherence.
I've gained about 15-20 pounds back, but I'm now much healthier overall.
I like how my brain works and I didn't like something affecting or changing that because I couldn't put the fork down. Easy decision for me
I'm not dismissing your overall point. I minimize my use of Adderall for that very reason.
Antibiotics and vaccines may not be completely free lunches, but they're very good at what they do.