50 every weekend is an exaggeration, but more people were murdered in Chicago from 2001 to 2021 than American soldiers died during the Global War on Terror (6,593 died in Iraq and Afghanistan vs. 11,561 in Chicago).

This is something of a red herring though as somewhere around 75% of those murders are black-on-black, with only a minority involving Latinos. Chicago primarily attracts attention not because of its murder rate (#22 in the country vs. Detroit at #5), but instead due to the size of its population and the prevalence of violent music that has come out of the region.