Concretely from my testing, both 20B and 120B has a lot higher refusal rate with Q8 compared to MXFP4, and lower quality responses overall. But don't take my word for it, the 20B weights are tiny and relatively effortless to try both versions and compare yourself.
edit:
So looking here https://ollama.com/library/gpt-oss/tags it seems ollama doesn't even provide the MXFP4 variants, much less hide them.
Is the best way to run these variants via llama.cpp or...?
Quantization - MXFP4 format
OpenAI utilizes quantization to reduce the memory footprint of the gpt-oss models. The models are post-trained with quantization of the mixture-of-experts (MoE) weights to MXFP4 format, where the weights are quantized to 4.25 bits per parameter. The MoE weights are responsible for 90+% of the total parameter count, and quantizing these to MXFP4 enables the smaller model to run on systems with as little as 16GB memory, and the larger model to fit on a single 80GB GPU.
Ollama is supporting the MXFP4 format natively without additional quantizations or conversions. New kernels are developed for Ollama’s new engine to support the MXFP4 format.
Ollama collaborated with OpenAI to benchmark against their reference implementations to ensure Ollama’s implementations have the same quality.
You can use the command `ollama show -v gpt-oss:120b` to see the datatype of each tensor.
Most gpt-oss GGUF files online have parts of their weights quantized to q8_0, and we've seen folks get some strange results from these models. If you're importing these to Ollama to run, the output quality may decrease.
Qwen3-Coder is in the same ballpark and maybe a bit better at coding
Hard to understand how this won't make all of the solutions for existing use cases commodity. I'm sure 2-3 years from now there'll be stuff that seems like magic to us now -- but it will be more-meta, more "here's a hypothesis of a strategically valuable outcome and heres a solution (with market research and user testing done".
I think current performance and leading models will turn out to have been terrible indicators for future market leader (and my money will remain on the incumbents with the largest cash reserves (namely Google) that have invested in fundamental research and scaling).
Caveat: That's just for the first prompt.
gpt-oss:20b on my M1 MBP is usable but quite slow.