I don’t use Android, but I understand uBlock Origin works with Firefox on it, which is kind of the gold standard on desktop, given the other browsers now restrict extensions in ways that make ad blockers less effective.

Use Firefox and install the uBlock Origin extension in Firefox.

I also suggest turning on the Annoyances and Cookie Banner filters in the uBO settings. They get rid of many popups.

Blocking in-app ads is a whole other ballgame. I don't have any suggestions for that.

You can actively poison your ad profile by using AdNauseum, which clicks on all the ads and then throws away the response. The actual ads are still hidden using UBO under the hood.

You can also use AdGuard+Tailscale to get DNS blocking of all ads on all devices. Tailscale will let you block in app ads, even on your phone even when on the cell network.

I combine both to block as much as possible.

Besides Firefox and unlock, I recommend rethink and the block lists, it will block ads in other apps.

uBlock Origin with Firefox. Nothing blocks as well, or from as trustworthy a provider.

Get Mullvad VPN. It has ad and many other DNS blockers built into the app.

Brave Browser