Yes. A useful analogy is to imagine being an adult in a world populated only by children. Aside from the social alienation of it being hard to relate to others, there would be practical matters. The entertainment would all be tedious and predictable, all the rationalizations for bad behavior would be transparently self-interested. Enhanced capabilities for observation, prediction, and planning would make you a super-hero at problem-solving, but really, what does that get you except repetitive unfulfilling effort? Don't sweat the small stuff is good advice, but you couldn't actually ignore the futility. Don't focus on the negative is good advice, but in a world like that pessimism and realism are the same thing. Anyone would be miserable. The good-aligned person would likely withdraw or self-lobotomize. More cynical characters would harden their heart, seize power, and become king of all the blind babies and try to yoke them together and build a pyramid or something. (Yes, I've recently reread Understand by Ted Chiang, No a pyramid is not a plot point per se ;)
Thankfully the situation isn't actually this extreme, but I think what we're talking about is just a difference in degree and not a difference in kind. Seeing more clearly than others seems very uncomfortable at best, and frequently maladaptive and/or a recipe for derangement.