What's wrong with it? That's good advice in almost any optimization or troubleshooting context where variables may interact.
Or, more modern Bayesian methods if you're more interested in getting the best results for a given hyperparameter sweep.
However, that is not to detract from the excellent effort made here and the great science being investigated. Write ups like this offer so much gold to the community.
And even then. If you’re an IC and your boss is saying, “incrementalism at the level of planning experiments,” and the goal is research, quit, because you will fail.