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Comment by sghiassy | Hacker News Reader

As an alcohol enthusiast on 12.5mg of Zepbound for the last several months, my ethanol consumption hasn’t diminished much

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As a beer enthusiast drinking unhealthy amounts rather too frequently, my drinking went way down when on Mounjaro.

(Maybe it wouldn't have made the same difference if I was into whisky instead of beer - with beer, I suspect it's the relatively large volume of drink involved that may have made it less appealing?)

Recently switched to Wegovy since the big Mounjaro price hikes here in the UK, and it seems rather less effective overall. Both beer and snacks are somewhat more appealing again :(

Interesting that Moujourno helped more than other brands. Might give that a try ;)

Mounjaro and Zepbound are chemically identical. Both are tirzepatide, just labeled for different use-cases. (Diabetes vs. weight loss)

Wegovy/Ozempic are semaglutide.

Interesting. I'm at zepbound 5mg and noticed that alcohol brings me no joy.

It used to be the case that 1-2 drinks would make me feel good, and introduce a craving for more (a "just one more will get me right" feeling).

But that's gone now. It's an amazing side effect.

I can also add I have little to zero side effects from Zepboubd if that adds anything

Side effects are generally rare, but it really depends on the person. I tried to start five times, and got massive side effects each time. The last time I started, I did my own protocol (started at 0.5mg every three days and increased a bit on every injection).

Now I'm up to 6mg and I'm not getting any side effects, but it also doesn't work for me! I lost 6kg at one point but the effects wore off and I gained the weight again.

None of my friends had this experience, for everyone else it's worked with no side effects. I really am cursed.

Be on the look out, I had really bad semaglutide side effects and had to stop. Thought microdosing would help, but the side effects just ramped up more slowly, culminating in what I assume was gastroparesis (my food just stopped digesting for over a day and I couldn’t eat despite being hungry and depleted, not to speak of the rest of the digestive process).

I also had drastically degraded (increased) resting heart rate, (decreased) heart rate variability, and exercise intolerance - a normal easy run started to make it feel like my heart would explode and gave me palpitations. Off it, I can run a 5K and beyond no problem, if my knees cooperate.

Food noise came into the picture much worse than baseline after I stopped, although it did eventually come down and I’ve been able to start losing weight again after a few months off. Berberine seems to help, at the expense of giving me nausea like semaglutide, but no other side effects.

have you lost weight?

Yup, 20lbs effortlessly. But I’ve plateaued despite going up in dosage. So still stuck at 200lbs

20lbs is still a fantastic achievement!

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