The article shows some advantages compared to plain virtual environments:

In principle, you can ‘activate’ this new virtual environment like any typical virtual environment that you may have seen in other tools, but the most ‘uv-onic’ way to use uv is simply to prepend any command with uv run. This command automatically picks up the correct virtual environment for you and runs your command with it. For instance, to run a script — instead of

   source .venv/bin/activate
   python myscript.py

you can just do

   uv run myscript.py