My guess is that comma-separated lists tend to be a feature of text that is attempting to be either comprehensively expository—listing all the possibilities, all the relevant factors, etc.—or persuasive—listing a compelling set of examples or other supporting arguments so that at least one of them is likely to convince the reader.
I find myself constantly editing my natural writing style to sound less like an AI so this discussion of em dash use is a sore spot. Personally I think many people overrate their ability to recognize AI-generated copy without a good feedback loop of their own false positives (or false negatives for that matter).
Computers unfortunately inherited a lot of this typewriter crap.
Related compromises included having only a single " character; shaping it so that it could serve as a diaeresis if overstruck; shaping some apostrophes so that they could serve as either left or write single quotes and also form a decent ! if overstruck with a .; alternatively, shaping apostrophe so that it could serve as an acute accent if overstruck, and providing a mirror-image left-quote character that doubled as a grave accent; and shaping the lowercase "l" as a viable digit "1", which more or less required the typewriter as a whole to use lining figures rather than the much nicer text figures.