I can't imagine how awful his friend and boss feel right now. He was behaving extremely erratically on his final stream to the point that they dropped by at 1am (granted that's more like 3pm in typical chess player time) to try to get him to stop playing, calm down, and just go to bed. They're obviously going to be asking themselves if they could have done more. The same is even true of Hikaru who recounted his last conversation with Danya, which was again about trying to help him up, and he teared up while again wondering if he could have done more.
And the catalyst for his decline was the cheating accusations. Yet the one 'mitigating' thing for Kramnik is that Danya really fell out of touch with reality with regards to the accusations. He made it clear that he felt many, if not most, people felt he was cheating. But in reality, basically nobody did. Kramnik has become basically a meme to the point that his accusations hold about as much weight as being called a naughty name online.
Of course from Danya's perspective it was going to be much more painful because he mentioned that Kramnik was one of his chess idols growing up. And people don't understand the amount of work it takes to become very good at chess. To then have one of your idols turn around and claim you're cheating, which is essentially pissing on all your work, is going to sting. And Danya had an immense, substantially more than average, amount of reverence for the title of world champion, which he felt that was causing people to believe Kramnik.
He felt the world was turning against him, but it simply wasn't. And the catalyst for this change was the accusations.
This [1] is from his final stream, and it's clear he was already at the breaking point. I feel most awful for his friend Bortnyk (one of the two voices you hear in the background there essentially having an intervention), he's going to be beating himself up thinking he could have done more, for years to come.
Everybody could see Danya deteriorating, but somehow I think nobody really realized just how 'real' it was. Magnus, who also regularly followed Danya's streams, has mentioned that he somewhat regrets not coming out publicly in defense of him. Probably in part because his views on cheating were already somewhat tainted at this point, and probably in part because nobody wanted to be the next person Kramnik started going after.
And another point in the video where it gets quite dark: https://youtu.be/112JImX_cWM?t=2615
Such an awful thing to see such an amazing person melt away and ultimately leave this world. Literally about a week ago I was recommending him on here to people trying to learn chess. His ability to teach was unparalleled.