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> I wish someone ran a proper study

There are several scientific publications on this. But I don't think the latest models are available as convenient plugins for IDA or Ghidra. Guessing variable and function names are considered as relatively easy nowadays. Types and structures are the challenges now.

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Even comments would be useful ("this function might be doing x, or maybe y")

I have never used it, but I think the GhidrAssist plugin does that (and more).

I use the following IDA pro MCP plugin for this: https://github.com/mrexodia/ida-pro-mcp

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