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Comment by glp1guide | Hacker News Reader

Not only that, there is a legitimate raft of companies lining up to make generics.

There’s one wrinkle though, legally importing prescription drugs from Canada isn’t really allowed in the US/UK AFAIK. HIMS is probably feverishly figuring out how to do that right now.

Shameless plug:

https://glp1guide.substack.com/p/another-glp1-generic-launch...

Also somewhat separately, injectable GLP1s are about to be upstaged by oral variants — orfoglipron for Eli Lilly and the Wegovy Pill for Novo.

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> Also somewhat separately, injectable GLP1s are about to be upstaged by oral variants — orfoglipron for Eli Lilly and the Wegovy Pill for Novo.

I believe that this gets a new patent, and will probably be a huge seller.

Absolutely -- certainly in their biggest markets they'll be able to protect those patents.

Both companies have thus far been unable to really stop compounding pharmacies and/or gray market suppliers from replicating though, and price negotiation with the government is definitely going to happen (Trump recently announced wanting $150 GLP1s, Novo's lawsuit against medicare price negotiation failed)... I do not have much faith in their ability to protect their pricing power for very long, which unfortunate for them is probably what's best for humanity and is very well known at this point.

I suspect a lot of the anti-vaxx movement is subconsciously motivated by fear of needles.

So yeah, I expect the pill form to be a huge seller!

This was made abundantly clear to me in 2020. It's a mass hysteria fueled by trypanophobia in a vast population of people who aren't very interested in self-analysis and understanding how their own behavior and thought patterns are driven by the amygdala.

One bit of evidence for this: SARMS are huge in the bodybuilding as "gateway steroids". They don't work, they have bad side effects, but hey, they're oral.

Nonsense.

You can use US prescription at online Canadian pharmacy and legally ship to US. This is how a lot of people save on drugs.

A bit late, but thanks for noting this -- I had no idea that this workaround was so well established. I don't often dive into concrete suggestions on how to obtain GLP1s because of how it could be perceived, but maybe I've underestimated how many people know how to do this right now.

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