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This looks rough for e2b.dev, Beam, and others in this space. Even with e2b's fresh $20M raise, taking on Cloudflare is going to be tough.

e2b have a python SDK thats why I would use them when I start a new project, (knowing Cloudflare they probably won't)

Why not use VMs from AWS (EC2) or GCP? E2b is built on top of GCP anyway.