I can't speak for everyone, but for myself the scenarios in this simulator basically don't affect my life at all. Annoying radio ad, "That's annoying". People team requests my participation at some event, "No thanks". Don't want to go to work, "oh well". If someone suggested we get coffee I'd be excited. I've never even considered not taking meds I've been prescribed. Other things seem normal to me. I put on ANC headphones at my office job all the time.
While going through the simulator, I was shocked with the response to some choices and situations. I was not aware that these things were so disruptive to some people.