I think LDL is a good biomarker, just not in isolation, and especially not a "one-size fits all" metric for individual humans.
I think LDL is a good biomarker, just not in isolation, and especially not a "one-size fits all" metric for individual humans.
Could you provide a few reputable clinical outcomes studies to support your statements? I was unaware of these risks.
These drugs require constant monitoring by physicians that understand what to look for, that are actively involved in adjusting dosage, for them to be even remotely safe. Muscle atrophy is considered an "uncommon side-effect", but that's just because most studies aren't performed over long enough periods of time. People tend to be kept on statins permanently. And that changes the safety factor considerably, as it does with any medicine taken over years.
My anecdotal evidence is based on multiple family members on these drugs and how even in Norway, with our fairly good healthcare system, it's not monitored sufficiently to avoid issues. There's a lot of strong feelings around statins as is apparent in the other response to my comment, but claims about them being safe except in outlier cases is simply not true.
See the bottom half of my comment at https://news.ycombinator.com/item?id=45446913 - significant muscle damage is exceedingly rare, and ~90% of the muscle pain reported in the RCTs ended up not being related to the statins at all.
Your claims are simply not backed by the data. These are some of the most prescribed and studied drugs on the planet.
These are some of the most studied medicines in human existence. They're not perfect and there are some people that do not tolerate them for one reason or another, but they are a small minority.