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The body needs SOME. Evolution doesn't care about when you die, just that you reproduce first. Even the highest cholesterol cases generally have kids old enough to have their own kids before they die. That is enough for evolution to not care.

As someone who lost the genetic lottery (has the high cholesterol gene) you bet I care. There is every reason to think that treating cholesterol will increase my lifespan - I'm hoping for quite a few more healthy years.

The body can produce needed cholesterol locally just fine. The PCKS9 inhibitor trials show that having basically no serum LDL is not harmful. People that have the genetic mutation that results in no PCKS9 have extremely low rates of CVD

> You could qualify your argument by saying that excess LDL is harmful.

It’s so obvious it doesn’t need to be stated dude.