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Comment by baxtr | Hacker News Reader

Anyone know how weight lifting might be related to this?

Weight lifting causes short bursts of inflammation right after training, which is part of the repair process. But in general it is considered very beneficial.

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I'd guess this is persistent, systemic inflammation. So I, as someone with IBD, have higher levels of CRP, so am probably a prime candidate for this kind of early death (despite having quite good cholesterol)

I believe IBD only had a slight impact on all cause mortality figures.

I dont know the direct answer to your question, and am not a Doctor nor researcher... but using a generally applicable health pattern -- it's important not to equate acute anything with chronic anything. Eg: Acute fat loss via exercising while fasting does not seem to relate to body composition changes over 12 weeks. Similarly the self protective process of hormesis seems to actually create greater health - like reactions to heat from sauna usages for example.

Fundamentally weight lifting should reduce inflammation, but at the same time I’m less certain about how things like protein powders or very high protein intake factor into this.

Weightlifting increases inflammation acutely, not chronically. But if you work out too much without enough rest, then the inflammation is chronic and that’s where the danger is. Over the long-term resistance training decreases CRP level levels when adequate rest is involved.

Everything has downsides. Exercise causes short term high blood pressure. Food generally decreases FMD. Etc.

Exercise in moderation is almost always worth it.

Exercise raises acute inflammation but lowers chronic inflammation

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