If the folks leading this effort in Boeing are smart, they will keep the size of the team as small as possible. Maybe they will even hire some people back to lead this effort... assuming they can find them.
My bet is that they will produce something not unlike what they already have in their lineup. It won't be boldly different in any way as technology that has worked elsewhere will just be cargo-culted forward into the "new" design. The biggest thing that will change are the handling characteristics since they won't have to match that of a previous aircraft.
Given that outcome, I (from the peanuts gallery) would design the aircraft to handle in some ideal way using MCAS-like automation to fix any deviation from that ideal, from the beginning. Of course, that's starting to head down the road of a more-Airbus-like design.
Also, passengers are probably going to start waking up to the realities of just how bad the air-travel experience in the US has become compared to so many foreign counterparts. If you want passengers to want your plane, design it without sardines in mind; People don't like being sardines.