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DTrace and SystemTap can insert probes in code if you're only interested in certain parts. If you want basic-block-level or instruction-level coverage, look at Pin, DynamoRIO, or Valgrind.

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Thanks, the latter two sound good. Pin seems to be a too generic acronym to Google it, what does it stand for?

Ah, good point; it took me a few tries to find the site myself. Apparently Pin isn't an acronym; it's just Pin.

http://www.pintool.org/

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