You would not be able to hit a drone with a bullet. Statistics are against you.
You use fancy AHEAD ammunition that disintegrates, and hopefully the drone with it.
https://en.wikipedia.org/wiki/AHEAD_ammunition
Yet, the bursts fired are expensive as fuck. Much more expensive than the drone.
Here you go: https://www.youtube.com/watch?v=bdwjcayPuag
But we've seen infantry effectively using shotguns in Ukraine as a defensive weapon against drones for the same reason hunters use shotguns to shoot birds on the wing, within your weapon's range the odds of a disabling hit are pretty high if you're trained.
So not sure why it has to be either a rifle bullet _or_ a massively overengineered defense contractor's very expensive super-duper-shotgun round.
Haha, wait, it's flak guns again, just redone for the 21st century. Ah bless.
If the choice is restricted by stand-off range, that is a different kettle of fish, maybe do bring back the, once considered entirely obsoleted by high altitude aircraft and missiles flak.
But in the here and now, regular shotguns are being used defensively, with a certain level of success, by infantry against drones in Ukraine.
What you linked seems like it would only be needed for an armored drone?
This AHDEA ammunition, while expensive, will bring down not only a drone, airplane or chopper, but also artillery grenades.
I suspect the same sort of skills displayed in Ukraine building home made Ardupilot based drones with optical final stage guidance could also be turned to building multi barrel "Phalanx-style" shotgun setups on manual plus computer-optical assisted aiming, in a form factor compact enough to be installed in the back of a Hilux. And that'd be very much the sort of mostly Commercial Off The Shelf approach that seems to do so well tipping the asymmetric warfare in Ukraine's favour in this war.