Long time MS Natural Ergonomic 4000 user. My search continues for an 80% split keyboard, where the important programming keys haven't been repositioned or worse, moved to a secondary layer (like braces/parenthesis, pipe/backslash, question mark/slash).
I do like the idea of thumb keys, but would probably need them as duplicates to the more traditional positions. I got a Keyboardio 100 which is absolutely beautiful, but 60% with layers for those above important keys just was too freaking hard.