To be clear, I'm not opposed to type hints. I use them everywhere, especially in function signatures. But the primary advantage to Python is speed (or at least perceived speed but that's a separate conversation). It is so popular specifically because you don't have to worry about type checking and can just move. Which is one of the many reasons it's great for prototypes and fucking terrible in production. You turn on strict type checking in a linter and all that goes away.
Worse, Python was not built with this workflow in mind. So with strict typing on, when types start to get complicated, you have to jump through all kinds of weird hoops to make the checker happy. When I'm writing code just to make a linter shut up something is seriously wrong.
Trying to ad typing to a dynamic language in my opinion is almost always a bad idea. Either do what Typescript did and write a language that compiles down to the dynamic one, or just leave it dynamic.
And if you want types just use a typed language. In a production setting, working with multiple developers, I would take literally almost any statically typed language over Python.
In my view it's always a mistake to try and tac static typing on top of a dynamic one. I think TS's approach is better than Python's, but still not nearly as good as just using a statically typed language.
The problem we are talking about in both Python and TS comes from the fact that they are (or compile down to) dynamic languages. These aren't issues in statically typed languages... because the code just won't compile it it's wrong and you don't have to worry about getting data from an untyped library.
I don't know a lot about Zod, but I believe the problem you are referring to is more about JavaScript then TS. JavaScript does a LOT of funky stuff at runtime, Python thank God actually enforces some sane type rules at runtime.
My point was not about how these two function at runtime. My point was that if you want to tac static typing onto a dynamic language, Typescripts approach is the better one, but even if can't fix the underlying issues with JS.
You could take a similar approach in Python. We could make a language called Tython, that is statically typed and then compiles down to Python. You eliminate an entire class of bugs at compile time, get a far more reliable experience then the current weirdness with gradual typing and linters, and you still get Pythons runtime type information to deal with things like interopt with existing Python code.
You would never have typing.TYPE_CHECKING to check if type checking is being done in TypeScript, for example, because type hints can't break Javascript code, something that can happen in Python when you have cyclic imports just to add types.