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> but this model wouldn’t exist without the large synthetic dataset produced by the more complex AF

This model could also have existed from natural data if we had access to enough of it.

Maybe, but then this seems more like an exercise in distillation rather than solving the original problem which is what the title "Folding proteins is simpler..." suggested to me at least. Part of the problem with any ML task is that data is usually limited and presumably far more limited than the amount of synthetic data you can generate.

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