I mapped it to a Colemak layout varient when I first got it. I was constantly discovering key combos that didn't quite work for whatever reason and made tweaks to the layout or the shortcuts in various editors. Forever tying my brain in knots learning and relearning mappings and combos. Then I'd frequently jump on other peoples computers/laptops to help out with small things and have to switch back to the old mode of thinking.
It ended up being a productivity sink rather than a boon. I don't know whether I would have crossed some inflection point if I had persevered, but there was always this fixed cost of tweaking shortcuts when using new software that was more burdensome than with a plain qwerty keyboard.
Maybe I was too ambitious and should have avoided the Colemak-esque layout, but I haven't managed to summon the stamina to give it a fair go again. I still use one half of it for gaming though. It's really sweet for that.