I've run my own mail for 10 years (postfix/dovecot/rspamd), no issues. Reverse DNS, SPF, and DKIM records need to be in place, but that's a small lift.
Well, one time I was unable to send mail to a guy with an ancient @att.com email address from his ISP. I got a nice bounce message back with instructions to contact their sysadmins to get unblocked.
To my surprise, they unblocked the IP of my mail server in a matter of hours.