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I doubt it would be a problem for the microbiome [1] but I would worry about the immune system. Would being inside in sterilized air all the time mean you can't go outside or into a forest without getting really sick?

[1] but who am I, it would still be worthwhile to check obviously

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The underlying thought is that outside air (such as a forest) gets UV sterilized by the sun. So this would bring inside air up to the sterilization level of outside air.

Ah, that makes sense.

That's not how the immune system works. Practice lets it learn how to fight specific bugs, it doesn't make it stronger overall.

I did not mean to imply at all that the immune system works like that.

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