But there is also definitely a place where your axiom systems become self-referential in the Busy Beaver and that is a qualitative change on its own. Aaronson and some of his students have put an upper bound on it, but the only question is exactly how loose it is, rather than whether or not it is loose. The upper bound is in the hundreds, but at [1] in the 2nd-to-last paragraph Scott Aaronson expresses his opinion that the true boundary could be as low as 7, 8, or 9, rather than hundreds.
ZFC is not some God given axiomatic system, it just happens to be one that mathematicians in a very niche domain have settled on because almost all problems under investigation can be captured by it. Most working mathematicians don't really concern themselves with it one way or another, almost no mathematical proofs actually reference ZFC, and with respect to busy beavers, it's not at all uncommon to extend ZFC with even more powerful axioms such as large cardinality axioms in order to investigate them.
Anyhow, just want to dispel a common misconception that comes up that somehow there is a limit in principle to what the largest BB(n) is that can be computed. There are practical limits for sure, but there is no limit in principle.
You can't categorically declare that something is unprovable. You can simply state that within some formal theory a proposition is independent, but you can't state that a proposition is independent of all possibly formal theories.