I remember desperately trying to put drivers in high memory, because Wing Commander 2 needed more memory if I was to get the precious images of the joystick moving. Slowly removing items, one by one from my autoexec.bat file, desperately hoping it was going to work, but then the creeping realisation that I would have to unload my soundcard drivers if I wanted a chance.
Or the time our bios randomly wiped its memory and my dad was convinced I had destroyed the harddrive. Thankfully I was told by a family friend that I would only have to turn on the BIOS and set it to # 31 (because somehow hard disk sizes, sectors, et cetra were all standardized) in order to access our precious 95 megabyte hard disk.