The less you can change about the product and environment, then automation run slower and less effectively.
Air liner operations could be automated, but the minimum equipment list would be more stringent, the destination airport would not be able to take any equipment out of service for maintenance, visibility minimums would increase, takeoff and landing operations would require more slack time.
Besides all of that, the owner of the airplane would still want to have some crew on board.
In short, it's not worth it yet.
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There is also the paradox of automation: Automation generally makes the hard parts harder and the easy parts easier.