I’ve done a couple of side gigs doing exactly that. I’m not really proficient in React, but I still had to do web development. For one project I used jQuery, and for the latest one I tried htmx — but it wasn’t quite enough, so I had to mix in some vanilla JS as well. Arguably, that’s not really a best-practice recommendation when working in a team, and I’d only consider it justifiable for smaller projects. Still, I got paid, so it worked out.