I think the "lethal trifecta" framing is useful and glad that attempts are being made at this! But there are two big, hard-to-solve problems here:

1. The "lethal trifecta" is also the "productive trifecta" - people want to be able to use LLMs to operate in this space since that's where much of the value is; using private / proprietary data to interact with (do I/O with) the real world.

2. I worry that there will soon be (if not already) a fourth leg to the stool - latent malicious training within the LLMs themselves. I know the AI labs are working on this, but trying to ferret out Manchurian Candidates embedded within LLMs may very well be the greatest security challenge of the next few decades.