Inter-node mesh with raw Wireguard is an exercise in patience to say the least; I have a few different colo sites, my house, my phone, LTE/5G hotspots, raspberry pi projects in the field, etc that I want to fully connect together.

Raw Wireguard is fine for a road warrior or site-to-site VPN setup as is common, but when you want multipoint peer-to-peer connections without routing through what might be a geographically distant point, magic DNS, etc, Tailscale really shines through.

If you're paranoid, enable https://tailscale.com/kb/1226/tailnet-lock or run https://headscale.net/ on your own as a control server.